Addition of MPV to the platelet count allows subtler disorders to be detected (when the platelet count is normal), and allows distinction of the cause of thrombocytopenia. Children with RSV undergoing bronchoscopy (n7) also had significantly lower MPV than children without RSV (n79) (8.8☑.0 vs. High MPV thus appears correlated with myeloproliferative disease or thalassemia and low MPV, with cytotoxic drugs or marrow hypoplasia. All had sepsis, splenomegaly, aplastic anemia, chronic renal failure, or a disease being treated with myelosuppressive drugs. 52 patients had an MPV that was inappropriately low for the platelet count (high, normal, or low). Learn more about laboratory tests, reference ranges, and understanding results. A low MPV may indicate inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. A low MPV test result may be a sign of: Certain cancers Side effects from certain medicines Aplastic anemia Autoimmune diseases Bacterial or viral infections Genetic conditions Alcohol use disorder (AUD) To learn what your results mean, talk with your provider. Multiple comparisons of MPV values in the four groups by. Seven patients had high MPV and high platelet count: causes included myeloproliferative disorders, inflammation, iron deficiency, and splenectomy, 25 patients had high platelet counts and normal MPV: the causes were inflammation, infection, sickle cell anemia, iron deficiency, or chronic myelogenous leukemia. Abnormally low MPV values may correlate with thrombocytopenia when it is due to impaired production of megakaryocytes in the bone marrow, such as in aplastic anemia. The mean MPV values in Groups 1-4 were 9.81 ± 0.13 fl, 10.34 ± 0.08 fl, 10.86 ± 0.09 fl, and 11.19 ± 0.11 fl, respectively (p < 0.001). The MPV can be useful for distinguishing between causes of thrombocytopenia (just like the MCV can provide guidance as to causes of anemia), but should never be used in isolation. Addition of a second variable, mean platelet volume (MPV), to the routine blood count allows classification of patients into 9 categories: high, low, or normal MPV, and high, low or normal platelet count. Automated hematologic analyzers (electrical impedance- or laser-based) can measure platelet volume (MPV), just like they can measure red blood cell volume ( MCV ). 15 patients had high MPV and normal platelet count: 12 had heterozygous thalassemia, and three had iron deficiency. Classification of platelet disorders has been based on the platelet count. 11 patients had high MPV and low platelet count: all had hyperdestructive causes. Addition of a second variable, mean platelet volume (MPV), to the routine blood count allows classification of patients into 9 categories: high, low, or normal MPV, and high, low or normal platelet count. Classification of platelet disorders has been based on the platelet count.
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